Biomaterials for
Tissue Repair and Regeneration
 
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MEMBERS

Adam Celiz

Lecturer (Assistant Professor) 

Adam graduated with a first class bachelor's degree from the University of Brighton in Pharmaceutical and Chemical Sciences in 2006. He then gained a PhD in Chemistry from the University of Cambridge in the Melville Laboratory for Polymer Synthesis in 2010. There he worked with Prof. Oren Scherman developing supramolecular polymeric materials based on hydrogen bonding motifs. Adam then pursued postdoctoral research at the University of Nottingham in the Advanced Materials and Healthcare Technologies division, with Professors Morgan Alexander and Martyn Davies. Here he developed high-throughput screening methodologies to discover new biomaterials for stem cell interactions. This work led to Adam being awarded an Early Career Researcher Award from the American Vacuum Society's Biomaterials Interfaces Division. Following this, Adam travelled 'across the pond' and was awarded a Marie Curie International Outgoing fellowship to work with Professor David Mooney at Harvard University in the Wyss Institute for Biologically Inspired Engineering. Here Adam developed biomaterial-based strategies to repair and restore tissues. Following this fellowship, Adam was awarded the Larry Hench Young Investigators Prize by the UK Society for Biomaterials. In August 2017, Adam joined the Department of Bioengineering at Imperial College London as Lecturer (Assistant Professor) to develop new biomaterials for tissue repair and regeneration.

Adam's research has been published in the journals Science, Nature Materials and Advanced Materials and has been highlighted by news agenies such as the BBCNewsweek, Popular Science and the Telegraph

Dr. Nicola Contessi-Negrini

Research Associate

Nicola graduated in 2014 in Biomedical Engineering at Politecnico di Milano (Milan, IT) and received his European PhD in Bioengineering in 2018 at Politecnico di Milano, working on the development of hydrogel-based scaffolds for soft tissue regeneration via advanced fabrication technologies. He has been a visiting researcher at the University of Brighton (Brighton, UK), Warsaw University of Technology (Warsaw, PL), and Massachusetts Institute of Technology (Cambridge, MA, USA). Nicola joined the Celiz Lab as PostDoctoral Research Associate in 2019 to develop biomaterials to support dental tissue engineering.

Dr. Charlie Winter

Research Associate

Charlie graduated with an MPharm degree in 2014 from University College London. He then registered with the General Pharmaceutical Council having spent a year training in hospital and industrial pharmacy. He then moved to academic research, undertaking a PhD and graduated in 2020 from Imperial College London. During his PhD, he developed stimuli-responsive drug delivery systems and investigated their cell-material interactions. In the Celiz lab, he will develop high throughput screening platforms for AI-driven biomaterial design.

Dr. Chunching Li

Research Associate

Chunching finished his PhD at Dept. Materials at Imperial College in 2020 (Molly Stevens). His PhD work utilizing buoyancy and magnetic force for facile gradient casting in selected biomaterials.  Prior his PhD, he finished his MEng in Biomedical Engineering at Taiwan University. Chunching joined the Celiz Lab as PostDoctoral Research Associate in 2020 to develop biomaterials for cardiac regeneration. 

Ignacio Medina-Fernandez

PhD student

Ignacio obtained his BSc Degree in Biomedical Engineering in the Polytechnic University of Valencia in Spain. In October 2016, he joined Imperial College to study an MSc in Biomedical Engineering with a specialisation in Biomaterials and Tissue Engineering. In 2017, Ignacio joined the Celiz Lab to develop scaffolds for dentine-pulp regeneration.

Kavya Ganabady

PhD student

Kavya obtained her MEng Degree in Biomedical Engineering in 2020 from Imperial College London. In October 2020, she joined the Celiz Lab as a PhD student to develop a hybrid hydrogel system for use as a tissue adhesive.

Leigh-Anne Gavin

Research Assistant

Leigh-Anne graduated with an MRes in Drug Discovery and Development from Imperial College London in 2019, where her work within the Tate group focused on targeting bacterial DNA repair in antimicrobial resistance.  Prior to this, she obtained a BSc in Chemical Sciences with Medicinal Chemistry at Technological University Dublin in 2016 and has worked within grade D pharmaceutical clean room environments as well as Covid-19 diagnostic laboratories.

Leigh-Anne joined the Celiz lab in 2021 as a Research Assistant to work in collaboration with the NHLI on the development of nonviral vectors for gene delivery. 

Yangshuo (Jessie) Hu

MRes Student

Jessie graduated from the University of Toronto with a Bachelor of Applied Science in Chemical Engineering in 2020. In summer 2018, she received the University of Toronto Excellence Award to work in Professor Michael Sefton's lab on a hydrogel for wound healing. She then spent a year as a research trainee in Professor Jeffrey Karp's lab at Brigham and Women's Hospital (Boston, MA, USA) where she researched nanoparticle delivery and tissue adhesives. Jessie conducted her undergraduate thesis in Professor Milica Radisic's Lab on an organ-on-a-chip platform for pancreatic cancer. In October 2020, Jessie joined the Celiz Lab to pursue an MRes in Bioengineering, working towards an in vitro model for lymphangiogenesis.

Syahirul Alim Ritonga 

MRes Student

Alim is currently studying in Medical Device Design and Entrepreneurship Program (MDDE) at Imperial College London. 

He finished his Bachelor degree in Gadjah Mada University, Indonesia in 2019. He participated in an exchange program at Tohoku University, Japan in 2017. In 2020, he joined Celiz Lab on research about hydrogel application. 

 Yipeng (Peggy) Pi

MRes student

Peggy graduated from Tufts University (Boston, MA) with a BS in Biochemistry in 2020. During her undergraduate research study, she focused on cardiomyocyte regeneration in Dr. Lauren Black's biomedical engineering lab. In October 2020, she joined Imperial College to pursue a Bioengeering MRes, focusing on hydrogel development for cardiomyocytes delivery.

Yidong Wang

MSc Student

Yidong (Frost) obtained his bachelor’s degree in Materials Science & Engineering from Beihang University and University of Pittsburgh. With interest in biomedical engineering, he continues his graduate study in BME at Imperial. At spare time he listens to music and watches movies. Travelling around the world is something he has always wanted to do.

Konstantinos Theodorou

MSc student

Konstantinos graduated in 2019 from the Aristotle University of Thessaloniki with an Integrated Master in Chemical Engineering with specialisation in Biotechnology. Afterwards, Konstantinos worked as a research assistant in Dr Amalia Aggeli’s group, where he also finshed his thesis focusing on gelatin / BMP-2 scaffolds for in vivoosteoconductivity.

Filippo Prestinoni Bocca

MSc Student

Filippo graduated from the University of Manchester with a BSc (Hons) in Biochemistry in 2020. During his undergrade he focused on the molecular basis of osseointegration and biofilm prevention. He also had the chance to conceptualise the development of an antibiotic secreting hydrogel with the focus of preventing Orthopaedic Device Related Infections (ODRI). In October 2020 he joined Celiz lab to focus on mesenchymal stem cell attachment and differentiation on regenerative hydrogel coatings.

 

MEMBERS

Adam Celiz

Lecturer (Assistant Professor) 

Adam graduated with a first class bachelor's degree from the University of Brighton in Pharmaceutical and Chemical Sciences in 2006. He then gained a PhD in Chemistry from the University of Cambridge in the Melville Laboratory for Polymer Synthesis in 2010. There he worked with Prof. Oren Scherman developing supramolecular polymeric materials based on hydrogen bonding motifs. Adam then pursued postdoctoral research at the University of Nottingham in the Advanced Materials and Healthcare Technologies division, with Professors Morgan Alexander and Martyn Davies. Here he developed high-throughput screening methodologies to discover new biomaterials for stem cell interactions. This work led to Adam being awarded an Early Career Researcher Award from the American Vacuum Society's Biomaterials Interfaces Division. Following this, Adam travelled 'across the pond' and was awarded a Marie Curie International Outgoing fellowship to work with Professor David Mooney at Harvard University in the Wyss Institute for Biologically Inspired Engineering. Here Adam developed biomaterial-based strategies to repair and restore tissues. Following this fellowship, Adam was awarded the Larry Hench Young Investigators Prize by the UK Society for Biomaterials. In August 2017, Adam joined the Department of Bioengineering at Imperial College London as Lecturer (Assistant Professor) to develop new biomaterials for tissue repair and regeneration.

Adam's research has been published in the journals Science, Nature Materials and Advanced Materials and has been highlighted by news agenies such as the BBCNewsweek, Popular Science and the Telegraph

Dr. Nicola Contessi-Negrini

Research Associate

Nicola graduated in 2014 in Biomedical Engineering at Politecnico di Milano (Milan, IT) and received his European PhD in Bioengineering in 2018 at Politecnico di Milano, working on the development of hydrogel-based scaffolds for soft tissue regeneration via advanced fabrication technologies. He has been a visiting researcher at the University of Brighton (Brighton, UK), Warsaw University of Technology (Warsaw, PL), and Massachusetts Institute of Technology (Cambridge, MA, USA). Nicola joined the Celiz Lab as PostDoctoral Research Associate in 2019 to develop biomaterials to support dental tissue engineering.

Dr. Charlie Winter

Research Associate

Charlie graduated with an MPharm degree in 2014 from University College London. He then registered with the General Pharmaceutical Council having spent a year training in hospital and industrial pharmacy. He then moved to academic research, undertaking a PhD and graduated in 2020 from Imperial College London. During his PhD, he developed stimuli-responsive drug delivery systems and investigated their cell-material interactions. In the Celiz lab, he will develop high throughput screening platforms for AI-driven biomaterial design.

Dr. Chunching Li

Research Associate

Chunching finished his PhD at Dept. Materials at Imperial College in 2020 (Molly Stevens). His PhD work utilizing buoyancy and magnetic force for facile gradient casting in selected biomaterials.  Prior his PhD, he finished his MEng in Biomedical Engineering at Taiwan University. Chunching joined the Celiz Lab as PostDoctoral Research Associate in 2020 to develop biomaterials for cardiac regeneration. 

Ignacio Medina-Fernandez

PhD student

Ignacio obtained his BSc Degree in Biomedical Engineering in the Polytechnic University of Valencia in Spain. In October 2016, he joined Imperial College to study an MSc in Biomedical Engineering with a specialisation in Biomaterials and Tissue Engineering. In 2017, Ignacio joined the Celiz Lab to develop scaffolds for dentine-pulp regeneration.

Kavya Ganabady

PhD student

Kavya obtained her MEng Degree in Biomedical Engineering in 2020 from Imperial College London. In October 2020, she joined the Celiz Lab as a PhD student to develop a hybrid hydrogel system for use as a tissue adhesive.

Leigh-Anne Gavin

Research Assistant

Leigh-Anne graduated with an MRes in Drug Discovery and Development from Imperial College London in 2019, where her work within the Tate group focused on targeting bacterial DNA repair in antimicrobial resistance.  Prior to this, she obtained a BSc in Chemical Sciences with Medicinal Chemistry at Technological University Dublin in 2016 and has worked within grade D pharmaceutical clean room environments as well as Covid-19 diagnostic laboratories.

Leigh-Anne joined the Celiz lab in 2021 as a Research Assistant to work in collaboration with the NHLI on the development of nonviral vectors for gene delivery. 

Yangshuo (Jessie) Hu

MRes Student

Jessie graduated from the University of Toronto with a Bachelor of Applied Science in Chemical Engineering in 2020. In summer 2018, she received the University of Toronto Excellence Award to work in Professor Michael Sefton's lab on a hydrogel for wound healing. She then spent a year as a research trainee in Professor Jeffrey Karp's lab at Brigham and Women's Hospital (Boston, MA, USA) where she researched nanoparticle delivery and tissue adhesives. Jessie conducted her undergraduate thesis in Professor Milica Radisic's Lab on an organ-on-a-chip platform for pancreatic cancer. In October 2020, Jessie joined the Celiz Lab to pursue an MRes in Bioengineering, working towards an in vitro model for lymphangiogenesis.

Syahirul Alim Ritonga 

MRes Student

Alim is currently studying in Medical Device Design and Entrepreneurship Program (MDDE) at Imperial College London. 

He finished his Bachelor degree in Gadjah Mada University, Indonesia in 2019. He participated in an exchange program at Tohoku University, Japan in 2017. In 2020, he joined Celiz Lab on research about hydrogel application. 

 Yipeng (Peggy) Pi

MRes student

Peggy graduated from Tufts University (Boston, MA) with a BS in Biochemistry in 2020. During her undergraduate research study, she focused on cardiomyocyte regeneration in Dr. Lauren Black's biomedical engineering lab. In October 2020, she joined Imperial College to pursue a Bioengeering MRes, focusing on hydrogel development for cardiomyocytes delivery.

Yidong Wang

MSc Student

Yidong (Frost) obtained his bachelor’s degree in Materials Science & Engineering from Beihang University and University of Pittsburgh. With interest in biomedical engineering, he continues his graduate study in BME at Imperial. At spare time he listens to music and watches movies. Travelling around the world is something he has always wanted to do.

Konstantinos Theodorou

MSc student

Konstantinos graduated in 2019 from the Aristotle University of Thessaloniki with an Integrated Master in Chemical Engineering with specialisation in Biotechnology. Afterwards, Konstantinos worked as a research assistant in Dr Amalia Aggeli’s group, where he also finshed his thesis focusing on gelatin / BMP-2 scaffolds for in vivoosteoconductivity.

Filippo Prestinoni Bocca

MSc Student

Filippo graduated from the University of Manchester with a BSc (Hons) in Biochemistry in 2020. During his undergrade he focused on the molecular basis of osseointegration and biofilm prevention. He also had the chance to conceptualise the development of an antibiotic secreting hydrogel with the focus of preventing Orthopaedic Device Related Infections (ODRI). In October 2020 he joined Celiz lab to focus on mesenchymal stem cell attachment and differentiation on regenerative hydrogel coatings.

Tianyuan Zhao

MSc Student

Tianyuan Zhao conducted his undergraduate studies of Biological Sciences at Imperial and  joined to the Celiz's lab for his master studies. His project is on tooth regeneration using gelatin cell co-culturing approach.

Lu Wang

MSc Student

Lu acquired her BSc in Environmental Engineering from the University of Ningbo (China). With experiences covering the environmental, chemical and biomedical fields, she joined the Celiz group. Her project is to develop polymer adhesive for bone fracture fixation.

 

NEWS

PUBLICATIONS

2019

Medina-Fernandez I.; Celiz A. D. “Acellular Biomaterial Strategies for Endodontic Regeneration” Biomaterials Science 2019, 44, 697. 2019 Emerging Investigators Issue

 

 

2018

 

Vining K. H.; Scherba J. C.; Bever A. M.; Alexander M. R.; Celiz A. D.*; Mooney D. J.* “Synthetic Light- Curable Polymeric Materials Provide a Supportive Niche for Dental Pulp Stem Cells” Advanced Materials 2018, 30, 1704486 – 1704489. 

2017

 

Li J.; Celiz A. D.*; Yang J.*; Yang Q.; Wamala I.; Whyte W.; Seo B. R.; Vasilyev N. V.; Vlassak J. J.; Suo Z.; Mooney D. J. “Tough Adhesives for Diverse Wet Surfaces” Science 2017, 357, 378 – 381.

Bauer A.; Gu L.; Kwee B.; Li A. W.; Dellacherie M.; Celiz A. D.; Mooney D. J. “Hydrogel Substrate Stress-Relaxation Regulates the Spreading and Proliferation of Mouse Myoblasts” Acta Biomaterialia 2017, 62, 82 – 90. 

2016

Amin Y. Y. I.; Runager K.; Simoes F.; Celiz A. D.; Taresco V.; Rossi R.; Enghild J. J.; Abildtrup L. A.; Kraft D. C. E.; Sutherland D. S.; Alexander M. R.; Foss M.; Ogaki R. “Combinatorial Biomolecular Nano-patterning for High-throughput Screening of Stem Cell Behavior” Advanced Materials 2016, 28, 1472 – 1476.

 

Patel A. K.; Tibbitt M. W.; Celiz A. D.; Langer R.; Davies M. C.; Denning C.; Alexander M. R.; Anderson D. G. “High Throughput Screening for Discovery of Materials that Control Stem Cell Fate” Current Opinion in Solid State and Materials Science 2016, 20, 202 – 211.

2015

 

Celiz A. D.*; Smith J. G. W.*; Patel A. K.; Hook A. L.; Rajamohan D.; George V. T.; Patel M. J.; Epa V. C.; Singh T.; Langer R.; Anderson D. G.; Allen N. D.; Hay D. C.; Winkler D. A.; Barrett D. A.; Davies M. C.; Young L. E.; Denning C.; Alexander M. R. “Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multi-Lineage Differentiation.” Advanced Materials 2015, 27, 4006 - 4012.

 

Patel A. K.; Celiz A. D.; Rajamohan D.;  Anderson D. G.; Langer R.; Davies M. C.; Alexander M. R.; Denning C. "A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays“ Biomaterials 2015, 61, 257 - 265.

 

Smith J. G. W.; Celiz A. D.; Patel A. K.; Short R. D.; Alexander M. R.; Denning C. “Scaling Human Pluripotent Stem Cell Expansion and Differentiation: Are Cell Factories Becoming a Reality?” Regenerative Medicine 2015, 10, 925 – 930.

2014

 

Celiz A. D.; Smith J. G. W.; Langer R.; Anderson D. G.; Barrett D. A.; Winkler D. A.; Davies M. C.; Young L. E.; Denning C.; Alexander M. R. “Materials for Stem Cell Factories of the Future.” Nature Materials 2014, 13, 570 - 579.

 

Celiz A. D.; Smith J. G. W.; Patel A. K; Langer R.; Anderson D. G.; Barrett D. A.; Young L. E.; Davies M. C.; Denning C.; Alexander M. R. “Chemically Diverse Polymer Microarrays and High Throughput Surface Characterization: A Method for Discovery of Materials for Stem Cell Culture” Biomaterials Science 2014, 2, 1604 - 1611.

 

Celiz A. D.; Harrington H. C.; Hook A. L. “High Throughput Assessment and Chemometric Analysis of the Interaction of Epithelial and Fibroblast Cells with a Polymer Library” Applied Surface Science 2014, 313, 926 – 935.

2013

Rao W.; Celiz A. D.; Scurr D. J.; Alexander M. R.; Barrett D. A. “Ambient DESI and LESA-MS Analysis of Proteins Adsorbed to a Biomaterial Surface Using In-Situ Surface Tryptic Digestion.” Journal of the American Society for Mass Spectrometry 2013, 24, 1927 – 1936.

 

Celiz A. D.; Hook A. L.; Scurr D. J.; Anderson D. A.; Langer, R.; Davies M. C.; Alexander, M. R. “ToF-SIMS imaging of a Polymer Microarray prepared using Ink-Jet Printing of Acrylate Monomers.” Surface and Interface Analysis 2013, 45, 202 - 205.

2010

 

Celiz A. D.; Scherman O. A. “A Facile Route to Ureidopyrimidinone-Functionalized Polymers via RAFT Polymerization.” Journal of Polymer Science Part A: Polymer Chemistry 2010, 48, 5833 – 5841.

2009

 

Celiz A. D.; Lee T. C.; Scherman O. A. “Polymer-Mediated Dispersion of Gold Nanoparticles Using Supramolecular Moieties on the Periphery.” Advanced Materials 2009, 21, 3937 - 3940.

2008

 

Celiz A. D.; Scherman O. A. “Controlled Ring-Opening Polymerization Initiated via Self Complementary Hydrogen-Bonding Units.” Macromolecules 2008, 41, 4115 - 4119. 

 
 

CONTACT

Royal School of Mines

Room 4.37

South Kensington Campus

Imperial College London

London, SW7 2AZ

UK

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